#1 Stem Cell Therapy for Joint Pain in Phoenix, AZ

Orthopedics

Orthopedics is a field of medicine to treat musculoskeletal trauma, spine diseases, sports injuries, and degenerative diseases. As we age,our joints can start to degenerate, old injuries can stop healing, and we’re at a higher risk for new injuries. Athletes, both young and old, put highly rigorous demands on their joints, muscles, ligaments, and tendons. Rather you’ve been fortunate enough to have a lot of birthdays or are an athlete (or former) recovering from musculoskeletal and joint pain can be difficult.

Fortunately advances in regenerative medicine have been made, and pioneering clinics like Innate Healthcare Institute, #1 stem cell treatment center in Phoenix, AZ, have applied the use of umbilical cord tissue mesenchymal stem cell therapy (UC-MSC) as an experimental treatment for pain from orthopedic disease and sports injuries.

Regenerative Medicine for Orthopedics and Sports Medicine

Umbilical Cord Mesenchymal Stem Cells are drastically changing our ability to treat diseases. In orthopedics and sports injuries these cells are transplanted to the site of injury to stimulate our bodies healing process. UC-MSCs can help heal damaged joints and injuries through multiple ways:

• Paracrine signaling (extracellular vesicles provide surrounding cells with growth factors, proteins, mRNAs, microRNAs, lipids, and DNA. These cells act as doctors distributing medicine to those cells in need.)
• Increasing cell viability and proliferation (decrease the osteogenic genes (COX2, COL10A1 and MMP13) 
• Suppressing inflammation – decreases production of inflammatory factors (TNF‐α, IL-1β, IL-6, IL-10)
• Inducing tissue repair and regeneration (promote chondrocyte proliferation) 
• Improving angiogenesis (producing more blood vessels)
• Offering protection against osteoarthritis progression 

Literature in the field of orthopedics with regenerative medicine such as umbilical cord stem cells, platelet-rich plasma, and prolotherapy have been ongoing for decades. Umbilical cord tissue has been defined as a very rich source for regenerative cells such as umbilical cord mesenchymal stem cells. 

Studies have shown MSCs have the ability to migrate to sites of inflammation of injured tissue. MSCs release trophic factors (e.g. exosomes) at the site of injury and affect differentiation, angiogenesis (the creation of new blood vessels), and cytokine signaling. MSCs also repair tissue through potent immunosuppressive and anti-inflammatory interactions with our immune system. They literally change the cells in the injured environment to promote a healing environment. 

A Systematic Review (meticulous summary of all the available primary research) was done on the effects of umbilical cord tissue mesenchymal stem cells would have on knee osteoarthritis (OA).

The researchers stated “Based on the results of this systematic review, many of the studies showed significant improvements following injection of UC-MSCs for the treatment of knee OA. Overall, the results illustrated positive clinical outcomes in the assessment of both pain and function at short-term follow-up. Furthermore, 3 studies included in this review evaluated the macroscopic ICRS score with all 3 reporting improvement in scores, indicating that UC-MSCs may actually repair cartilage damage from knee OA.”

Not only are UC-MSCs great at relieving pain after administration, they can significantly improve the function of the joint as well. A 2020 publication (Ann Transl Med 2021;9(6):452), a systematic review with conventional and network meta-analyses of randomized controlled trials, stated umbilical cord MSCs as the best source of stem cell treatments for functional improvement, compared to bone marrow and adipose stem cells. While all sources of MSCs showed improvements over placebo, the study reported UC-MSCs were considered to be the most effective cells for functional improvement (SMD =−1.02, 95% CI: −1.90 to −0.13, P=0.024) and that UC-MSCs have the largest probability of being the best treatment option for pain relief (SUCRA =85.3%).

How the cells are cultured/grown/handled is highly reflective of how well they can perform at healing, this is why it’s so imperative to find a clinic that is experienced in the field, and art, of regenerative medicine with umbilical cord tissue.

Innate Healthcare Institute is your no. 1 choice when it comes to stem cell therapy for joint pain in Phoenix, AZ. So, if you’re an athlete suffering from sports injury or orthopedic disease, and can’t stand joint pain – we’re here to help you recover and perform better than ever before!

If you can’t explain it simply, you don’t understand it well enough.” -Albert Einstein

Simply put, our regenerative techniques of utilizing umbilical cord mesenchymal stem cells can dramatically improve both pain and function due to damaged joints. Athletes can heal faster and better, return to their sport and play longer than before. Athletes benefit from this therapy over surgery as there is minimal downtime. Whereas most surgeries take months of downtime and rehabilitation, UC-MSC therapies have less significant downtime and athletes can return to their training and sport faster. Those that have been inactive due to pain can live more vibrantly and do things they haven’t done in years.

After transplantation, through a simple, minimally invasive injection, damaged tissue starts to repair. Typically within 1-2 weeks patients are noticing a decrease in pain, after 1-2 months a significant improvement in function can return (individuals vary).

Innate Healthcare Institute is a unique entity in the field of stem cell therapy for joint pain as our laws and medical board in the state of Arizona allow for the administration of higher doses of umbilical cord mesenchymal stem cells typically only found in over-seas clinics. The course of treatment is therefore between the doctor and the patient.

So, if you need stem cell therapy for orthopedic or sports medicine in Phoenix, AZ, call us at 602.603.3118 or email info@innatehealthcare.org to schedule an appointment or for a free consultation if you have any questions.

References:
Atala, Anthony, et al. Principles of Regenerative Medicine. Elsevier ; Academic Press, 2019.

Cooper, Grant, et al., editors. Regenerative Medicine for Spine and Joint Pain. Springer, 2020.

Dhillon, Jaydeep, et al. “Umbilical Cord–Derived Stem Cells for the Treatment of Knee Osteoarthritis: A Systematic Review.” Orthopaedic Journal of Sports Medicine, vol. 10, no. 7, 2022, p. 232596712211044., https://doi.org/10.1177/23259671221104409.

Kim, Y.S., et al. “Assessment of Clinical and MRI Outcomes after Mesenchymal Stem Cell Implantation in Patients with Knee Osteoarthritis: A Prospective Study.” Osteoarthritis and Cartilage, vol. 24, no. 2, 2016, pp. 237–245., https://doi.org/10.1016/j.joca.2015.08.009.

Liang, Hanguang, et al. “Progress in the Treatment of Osteoarthritis with Umbilical Cord Stem Cells.” Human Cell, vol. 33, no. 3, 23 May 2020, pp. 470–475., https://doi.org/10.1007/s13577-020-00377-z.

Malanga, Gerard A., and Victor Ibrahim. Regenerative Treatments in Sports and Orthopedic Medicine. Demos Medical, an Imprint of Springer Publishing, 2018.

Marmotti, A., et al. “Allogeneic Umbilical Cord-Derived Mesenchymal Stem Cells as a Potential Source for Cartilage and Bone Regeneration: An in Vitro Study.” Stem Cells International, vol. 2017, 16 Nov. 2017, pp. 1–16., https://doi.org/10.1155/2017/1732094.

Matas, Jose, et al. “Umbilical Cord-Derived Mesenchymal Stromal Cells (Mscs) for Knee Osteoarthritis: Repeated MSC Dosing Is Superior to a Single MSC Dose and to Hyaluronic Acid in a Controlled Randomized Phase I/II Trial.” Stem Cells Translational Medicine, vol. 8, no. 3, 28 Dec. 2018, pp. 215–224., https://doi.org/10.1002/sctm.18-0053.

Wang, Hao, et al. “The Human Umbilical Cord Stem Cells Improve the Viability of OA Degenerated Chondrocytes.” Molecular Medicine Reports, 2018, https://doi.org/10.3892/mmr.2018.8413.

Wei, Zhen-Jie, et al. “Which Is the Most Effective One in Knee Osteoarthritis Treatment from Mesenchymal Stem Cells Obtained from Different Sources? —a Systematic Review with Conventional and Network Meta-Analyses of Randomized Controlled Trials.” Annals of Translational Medicine, vol. 9, no. 6, 2021, pp. 452–452., https://doi.org/10.21037/atm-20-5116.

Yubo, Ma, et al. “Clinical Efficacy and Safety of Mesenchymal Stem Cell Transplantation for Osteoarthritis Treatment: A Meta-Analysis.” PLOS ONE, vol. 12, no. 4, 27 Apr. 2017, https://doi.org/10.1371/journal.pone.0175449.