What is Autism?
Autism, also refered to as autism spectrum disorder (ASD), refers to a broad range of conditions. There is no ‘one size fits all’ approach to autism. Symptom include challenges with social skills, repetitive behaviors, speech and nonverbal communication. It is commonly thought that autism is a influenced by a combination of neurological, gastrointestinal and immune system factors. Leading many experts to state that ASD is an autoimmune condition (include hyperlink to autoimmune page).
Autoimmune disease is a category representing more than 80 conditions. These conditions are highlighted by a person’s own immune system attacking healthy tissue. A healthy immune system defends against infection and disease, repairing the body and even preventing cancers. However, in autoimmune disease the immune system mistakes healthy tissue as “bad” and attacks it. This weakens the function of the tissue and can even turn life threatening.
What are the symptoms of Autism?
As stated above there are no set signs and symptoms for autism. According to autismspeaks.org not all children show all the signs and many children who don’t have autism show a few signs. Here are some signs and symptoms that may indicate ASD:
- Few or no big smiles or other warm, joyful and engaging expressions
- Limited or no eye contact
- Little or no back-and-forth sharing of sounds, smiles or other facial expressions
- Little or no babbling
- Little or no back-and-forth gestures such as pointing, showing, reaching or waving
- Little or no response to name
- Very few or no words
- Very few or no meaningful, two-word phrases (not including imitating or repeating) At any age
- Loss of previously acquired speech, babbling or social skills
- Avoidance of eye contact
- Persistent preference for solitude
- Difficulty understanding other people’s feelings
- Delayed language development
- Persistent repetition of words or phrases (echolalia)
- Resistance to minor changes in routine or surroundings
- Restricted interests
- Repetitive behaviors (flapping, rocking, spinning, etc.)
- Unusual and intense reactions to sounds, smells, tastes, textures, lights and/or colors
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How can stem cells help with ASD?
Mesenchymal stem cells (aka medicinal signaling cells) are specialized cells in our body designed to improve the immune system and restore damaged tissue. Stem cell therapy with human umbilical cord tissue derived mesenchymal stem cells (UC-MSCs) corrects the inflammatory process by modulating the immune system from a pro-inflammatory attacking state to an anti-inflammatory healthy state. They also have the ability to regenerate damage done from the autoimmune attack. Stem cells do this by secreting healing activators such as growth factors, cytokines, and exosomes to the surrounding environment.
In ASD it is proposed that there is an imbalance in the innate and adaptive immunity. Meaning there’s an alteration leading to the body to be in a pro-inflammatory state. Transplanted stem cells are able to increase anti-inflammatory cytokine production. This is done through multiple mechanisms of actions:
- Paracrine secretion of several anti-inflammatory and survival-promoting molecules (ie, VEGF, HGF, BDNF, NGF)
- Neuroprotective effects
- Hypoimmunogenic and immunosuppressive properties
This therapy is the most highly sophisticated treatment for autoimmune disease management since it not only “manages” the pain and symptoms of autoimmune diseases but also heals and regenerates the tissue naturally. There’s an intricate process called the Th1 and Th2 immune response which is out of balance in autoimmune disease. Stem cell, aka medicinal signaling cells, signal the immune system to become balanced through an increase of Th3, Th17, and T-regulatory cells. This is just a small fraction of what’s going on when this amazing medicine is put in our body.
For the technically minded patients, MSCs inhibit autoimmune innate immune activation by blocking dendritic cell maturation, suppressing macrophage activation, and producing IL-1 antagonist and IL10 which block antigen presentation and perpetuating autoimmunity. These are just some of the known mechanisms. Also, an increase in T-reg cells helps balance the immune system and keeps it out of a pro-inflammatory state.
How ASD treated with stem cell therapy?
The administration of the stem cell medicine is chosen by the doctor as what would be the best route for the patient. We also offer a specialized approach at Innate with also delivering cells intranasally, which is simply spraying them them in the sinuses with a specialized tool. There is a bundle of nerves that travels directly to the brain. If you’re curious or would like to impress your friends, this is referred to as sphenopalatine ganglion administration.
What are the advantages of using allogenic (not the patient’s own) umbilical cord tissue derived stem cells?
- Umbilical cord tissue is one of the most abundant sources of stem cells, producing a greater number and quality of stem cells.
- Using UC-MSC means there’s no need for invasive procedures seen in bone-marrow or adipose derived stem cells. These methods also tend to produce inferior numbers and poorer quality of stem cells.
- There is evidence that UC-MSCs are a more viable source compared to other MSC sources. Meaning they perform better at what MSCs do naturally.
- UC-MSCs can be administered safely numerous times, each time adding more and more benefit. Unlike steroid injections which end up damaging your joints even more if administered to often.
How is Innate Healthcare’s stem cell therapy protocols different from other clinics?
- We treat with very high, and safe, doses.
- Included with the treatment is other forms of healing, such as IV nutrients, and acupuncture, to facilitate the healing.
- Herbal medicines, nutraceuticals, and nutritional guidelines are provided.
- Patients are encouraged to return to the clinic for additional care during following months.
How can I get evaluated?
Simply set-up a consultation and exam with us and we’ll provide you with the best recommendation for treatment(s). Schedule yourself by clicking the link below or call us at 602.456.5383.